ATR anticorps (AA 400-450)

N° du produit ABIN7450015

Cet anticorps Lapin Polyclonal détecte spécifiquement ATR dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour ATR anticorps (AA 400-450) (ABIN7450015)

Antigène: ATR (ATR serine/threonine kinase (ATR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-ATR anticorps

Épitope: AA 400-450

Fonction: Rabbit anti-ATR Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 400 and 450

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur ATR

Antigène: ATR (ATR serine/threonine kinase (ATR))

Autre désignation: ATR

Sujet: Background: ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.

ID gène: 545

NCBI Accession: NP_001175

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus